New Horizons to Periopathogenesis & Microbiology

Title: New Horizons to Periopathogenesis & Microbiology
Author: Dr. Sonam Pandey

ISBN: 978-93-7461-262-0

The field of periodontology has witnessed remarkable evolution over recent decades, transitioning from a discipline centered largely on clinical observations to one grounded in advances in molecular biology, immunology, and microbiology. Periodontal diseases, once considered solely plaque induced, are now understood as complex, multifactorial conditions governed by dynamic interactions between microbial biofilms, host immune responses, genetic predisposition, and systemic factors.

New Horizons to Perio Pathogenesis is an effort to highlight these contemporary perspectives that are reshaping our understanding of disease onset and progression. Current research underscores the significance of microbial dysbiosis, host-mediated inflammatory pathways, epigenetic regulation, and the impact of systemic conditions such as diabetes mellitus and cardiovascular disorders. In addition, growing evidence surrounding mechanisms like the RANK/RANKL/OPG pathway, AGE–RAGE axis, and matrix metalloproteinase activity has deepened insight into periodontal tissue breakdown and alveolar bone loss.

This book seeks to integrate classical principles with emerging scientific developments, offering a cohesive overview of both foundational knowledge and recent innovations. It also brings attention to advancements in diagnostic and research technologies, including genomics, proteomics, and salivary biomarkers, which are driving the shift toward precision based periodontal care.

Designed for postgraduate students, academicians, and practicing clinicians, this work aims to encourage analytical thinking and inspire continued research in this rapidly advancing domain. A thorough understanding of these evolving concepts is essential for the development of more effective, individualized, and predictive approaches to periodontal therapy.

Dr. Sonam Pandey